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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLCG2 All Species: 23.33
Human Site: S679 Identified Species: 46.67
UniProt: P16885 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16885 NP_002652.2 1265 147870 S679 R K R E G S D S Y A I T F R A
Chimpanzee Pan troglodytes XP_001147944 1265 147906 S679 R K R E G S D S Y A I T F R A
Rhesus Macaque Macaca mulatta XP_001111677 1265 147898 S679 R K R E G S D S Y A I T F R A
Dog Lupus familis XP_546812 1252 146274 S679 R R R E G T D S Y A I T F R A
Cat Felis silvestris
Mouse Mus musculus Q8CIH5 1265 147573 S679 R K R E G T N S Y A I T F R A
Rat Rattus norvegicus P24135 1265 147716 S679 R K R E G T D S Y A I T F R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508105 991 115582 G426 H C R I N Q D G R H F V L G T
Chicken Gallus gallus Q2VRL0 637 72514 R72 I Y R A I V H R N E F H E I F
Frog Xenopus laevis Q32NH8 758 87399 E193 E S G T L E G E E F V L F Y K
Zebra Danio Brachydanio rerio A5D6R3 784 89362 E219 D G R L D H V E I E E F C R E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624101 1134 132613 S569 Y R S H P L R S Q E F L I T L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784329 940 107748 A375 R L F T I G S A Q F E S L A E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98 94.4 N.A. 94.1 94.7 N.A. 62.7 20.7 22.1 21.2 N.A. N.A. 40.9 N.A. 32.9
Protein Similarity: 100 99.9 99.2 97 N.A. 97.1 97.3 N.A. 67.8 33.2 37.5 34.9 N.A. N.A. 59.1 N.A. 49
P-Site Identity: 100 100 100 86.6 N.A. 86.6 93.3 N.A. 13.3 6.6 6.6 13.3 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 6.6 13.3 13.3 N.A. N.A. 13.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 0 0 9 0 50 0 0 0 9 50 % A
% Cys: 0 9 0 0 0 0 0 0 0 0 0 0 9 0 0 % C
% Asp: 9 0 0 0 9 0 50 0 0 0 0 0 0 0 0 % D
% Glu: 9 0 0 50 0 9 0 17 9 25 17 0 9 0 17 % E
% Phe: 0 0 9 0 0 0 0 0 0 17 25 9 59 0 9 % F
% Gly: 0 9 9 0 50 9 9 9 0 0 0 0 0 9 0 % G
% His: 9 0 0 9 0 9 9 0 0 9 0 9 0 0 0 % H
% Ile: 9 0 0 9 17 0 0 0 9 0 50 0 9 9 0 % I
% Lys: 0 42 0 0 0 0 0 0 0 0 0 0 0 0 9 % K
% Leu: 0 9 0 9 9 9 0 0 0 0 0 17 17 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 9 0 9 0 9 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 9 0 0 17 0 0 0 0 0 0 % Q
% Arg: 59 17 75 0 0 0 9 9 9 0 0 0 0 59 0 % R
% Ser: 0 9 9 0 0 25 9 59 0 0 0 9 0 0 0 % S
% Thr: 0 0 0 17 0 25 0 0 0 0 0 50 0 9 9 % T
% Val: 0 0 0 0 0 9 9 0 0 0 9 9 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 9 0 0 0 0 0 0 50 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _